Symbol
Name
ID

Clcn5
chloride channel, voltage-sensitive 5
MGI:99486

Phenotype annotations related to renal/urinary system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Hyperphosphaturia

Renal phosphate wasting

Hypercalciuria

Hematuria

Microscopic hematuria

Hyperuricosuria

Glycosuria

Beta 2-microglobulinuria

Proteinuria

Low-molecular-weight proteinuria

Aminoaciduria

Hyposthenuria

Glomerular sclerosis

Focal segmental glomerulosclerosis

Renal tubular atrophy

Tubulointerstitial fibrosis

Nephrocalcinosis

Nephrolithiasis

Renal insufficiency

Chronic kidney disease

Stage 5 chronic kidney disease

Proximal tubulopathy

Non-acidotic proximal tubulopathy

Disease(s) Associated with CLCN5

Dent disease

low molecular weight proteinuria with hypercalciuric nephrocalcinosis

X-linked nephrolithiasis type I

X-linked recessive hypophosphatemic rickets

Mouse Phenotypes

renal/urinary system phenotype

hyperglutaminuria

hydroxyprolinuria

hyperthreoninuria

decreased urine creatinine level

aminoaciduria

cystinuria

increased urine glucose level

abnormal renal protein reabsorption

increased urine calcium level

increased urine insulin level

decreased urine pH

increased urine phosphate level

increased urine protein level

increased urine beta2-microglobulin level

abnormal kidney corticomedullary boundary morphology

nephrocalcinosis

abnormal renal transport

polyuria

Availability

Mouse Genotype

Clcn5^tm5.1Tjj/Clcn5⁺

Clcn5^tm1Gug/Y

Clcn5^tm1Tjj/Y

Clcn5^tm2.1Tjj/Y

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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